منابع مشابه
HAMLET interacts with histones and chromatin in tumor cell nuclei.
HAMLET is a folding variant of human alpha-lactalbumin in an active complex with oleic acid. HAMLET selectively enters tumor cells, accumulates in their nuclei and induces apoptosis-like cell death. This study examined the interactions of HAMLET with nuclear constituents and identified histones as targets. HAMLET was found to bind histone H3 strongly and to lesser extent histones H4 and H2B. Th...
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متن کاملChromatin assembly in isolated mammalian nuclei.
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Using a series of 105 renal cell carcinomas (RCCs) we investigated whether features quantitatively describing the appearance of Feulgen-stained nuclei and, more particularly, of their chromatin (on the basis of computer-assisted microscopy) can contribute any significant prognostic information. Thirty morphonuclear and 8 nuclear DNA content-related variables were thus generated. The actual prog...
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ژورنال
عنوان ژورنال: Nature
سال: 1949
ISSN: 0028-0836,1476-4687
DOI: 10.1038/164109a0